Left Ventricular Function and Hypertrophy

Left ventricular (LV) function and hypertro:hy, assessed during cardiac catheterization by quantitative biplane angiocardiography, were re'ated to posteatheterization course in 36 patients found to have cardiomyopathy with depressed eject.on fraction (EF). EF ranged from 0.09 to 0.41, LV mass (M) from 99 to 317 g/m2, LV end-diastolic volume (V) from 104 to 347 ml/m2, and ratio of M/V from 0.66 to 1.63. In this study, EF was used as an index of LV function; M/V ratio was considered to represent a relative degree of LV hypertrophy. Postcatheterization survival rates (PCSR) for all patients at 12, 24, and 36 months were 68.8+± 7.8%, 49.9 -+9.2%, and 32.8 10.2%. The 36-month PCSR was significantly higher for patients (N = 15) with EF > 0.20 (75.1 + 14.5%) than for those (N = 21) with wEF < 0.20 (0%) (P < 0.01). The 36-month PCSR was also significantly higher for patients (N = 19) with M/V ratio > 0.90 (53.6+ 14.8%) than for those (N= 17) with M/V ratio <0.90 (12.4 10.4%) (P <0.05). M/V ratio appeared to influence survival at least in part independently of EF. For patients with EF > 0.20 M/V ratio > 0.90 was associated with a higher 36-month PCSR (100%) than was M/V ratio < 0.90 (25.0 6.5%). Likewise, for patients with EF < 0.20, M/V ratio > 0.90 was associated with a higher 24-month PCSR (65.1 16.8%) than was M/V ratio <0.90 (6.8 9.1%); but at 36 months, PCSR was < 10% for both subgroups. Patients (N = 16) with mitral regurgitation (MR) > 0.70 liters/min/m2 had a mean value for